atav1st · 5 points · *
The most important factor is increased homozygosity: Every human has two slightly different copies ("alleles") of the same gene in his DNA, one from his mother, one from his father- some of those alleles would cause or contribute to disease (for example because they are not working properly), but are kept in check by the second, healthy allele of the gene. Now, if you mate two closely related animals (who of course share many alleles already) the chance of getting two defect alleles for a given gene rises.
So, the offspring of related persons doesn't HAVE to be sick, it's just that the chance is vastly higher than in others. And of course it doesn't get better in time (with more inbreeding using the same varieties of the two ancestors).
So, the offspring of related persons doesn't HAVE to be sick, it's just that the chance is vastly higher than in others. And of course it doesn't get better in time (with more inbreeding using the same varieties of the two ancestors).
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